SHP099 is a highly potent (IC50 = 0.071uM),selective and orally bioavailable small-molecule SHP2 inhibitor. The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism. SHP099 suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models. Reference: Ran, H., Tsutsumi, R., Araki, T.,Neel, B. G., Sticking It to Cancer with Molecular Glue for SHP2. Cancer Cell 2016, 30, 194-196. DOI: 10.1038/nature18621
| Product Name |
SHP099 |
| Synonyms |
|
| CAS Number |
1801747-42-1 |
| Related CAS |
|
| Molecular Formula |
C16H19Cl2N5 |
| Molecular Weight |
352.26 |
| SMILES |
CC1(N)CCN(CC1)C1=CN=C(C(N)=N1)C1=C(Cl)C(Cl)=CC=C1 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
