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SHP099 is a highly potent (IC50 = 0.071uM),selective and orally bioavailable small-molecule SHP2 inhibitor. The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism. SHP099 suppresses RAS–ERK signalling to inhibit the proliferation of receptor-tyrosine-kinase-driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models. Reference: Ran, H., Tsutsumi, R., Araki, T.,Neel, B. G., Sticking It to Cancer with Molecular Glue for SHP2. Cancer Cell 2016, 30, 194-196. DOI: 10.1038/nature18621
Product Name SHP099
CAS Number 1801747-42-1
Related CAS
Molecular Formula C16H19Cl2N5
Molecular Weight 352.26
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only