5-(and-6)-carboxyl-2',7'-dichlorofluorescein diacetate



5-10 business days

5-(and-6)-carboxyl-2,7-dichlorofluorescein diacetate (Carboxy-DCFDA, CDCF) can passively diffuse into cells and is colorless and nonfluorescent until the acetate groups are cleaved by intracellular esterases to yield the fluorescent fluorophore, 5-(and-6)-carboxy-2,7-dichlorofluorescein. With a pKof 4.8, this dye can be used as an acidic pH sensor. It has been used as a fluorescent substrate/probe to study the distribution and mechanism of action of multidrug resistance-associated protein 2 (Mrp2).

Product Name: 5-(and-6)-carboxyl-2',7'-dichlorofluorescein diacetate
Synonyms: Carboxy-DCFDA
CAS Number: 127770-45-0
Molecular Formula: C25H14Cl2O9
Molecular Weight: 529.28
SMILES: CC(=O)OC1=C(Cl)C=C2C(OC3=CC(OC(C)=O)=C(Cl)C=C3C22OC(=O)C3=CC(=CC=C23)C(O)=O)=C1.CC(=O)OC1=C(Cl)C=C2C(OC3=CC(OC(C)=O)=C(Cl)C=C3C22OC(=O)C3=CC=C(C=C23)C(O)=O)=C1
Purity (HPLC): ≥ 95%
Shipping Conditions: room temperature
Storage Conditions: Refrigerated
Regulatory Statement: For Research Use Only