Compound AN2 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). AN2 reduces the levels of mHTT in an allele-selective manner in cultured Huntington disease (HD) mouse neurons. Reference: Li, Z., Wang, C., Wang, Z., Zhu, C., Li, J., Sha, T., Ma, L., Gao, C., Yang, Y., Sun, Y., Wang, J., Sun, X., Lu, C., Difiglia, M., Mei, Y., Ding, C., Luo, S., Dang, Y., Ding, Y., … Lu, B. (2019). Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds. Nature, 575(7781), 203–209. https://doi.org/10.1038/s41586-019-1722-1
| Product Name |
AN2 |
| Synonyms |
5,7-dihydroxy-4-phenylcoumarin |
| CAS Number |
7758-73-8 |
| Related CAS |
|
| Molecular Formula |
C15H10O4 |
| Molecular Weight |
254.241 |
| SMILES |
OC1=CC(O)=C2C(OC(=O)C=C2C2=CC=CC=C2)=C1 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
