BODIPY FL Thalidomide is a high-affinity fluorescent probe for the human Cereblon protein, with a Kd value of 3.6 nM. The BODIPY FL thalidomide-mediated Cereblon Time-Resolved Fluorescence Resonance Energy Transfer (TR-FRET) assay, is highly sensitive, selective, and stable. As reported in the the follwoing article: Wenwei Lin, Yongtao Li, Jaeki Min, Jiuyu Liu, Lei Yang, Richard E. Lee, and Taosheng Chen, Development of BODIPY FL Thalidomide As a High-Affinity Fluorescent Probe for Cereblon in a Time-Resolved Fluorescence Resonance Energy Transfer Assay
Bioconjugate Chemistry 2020 31 (11), 2564-2575. DOI: 10.1021/acs.bioconjchem.0c00507
| Product Name: |
BODIPY FL Thalidomide |
| Synonyms: |
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| CAS Number: |
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| Molecular Formula: |
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| Molecular Weight: |
732.59 |
| SMILES: |
| CC1=CC(C)=[N]2C1=CC1=CC=C(CCC(=O)NCCCCCCCCNC(=O)COC3=C4C(=O)N(C5CCC(=O)NC5=O)C(=O)C4=CC=C3)N1[B]2(F)F |
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| Purity (HPLC): |
95% |
| Shipping Conditions: |
room temperature |
| Storage Conditions: |
Refrigerated |
| Regulatory Statement: |
For Research Use Only |
