Avadomide (CC-122) is an orally active cereblon modulator. It promotes degradation of Aiolos and Ikaros proteins. Reference: Hagner, P. R., Man, H. W., Fontanillo, C., Wang, M., Couto, S., Breider, M., Bjorklund, C., Havens, C. G., Lu, G., Rychak, E., Raymon, H., Narla, R. K., Barnes, L., Khambatta, G., Chiu, H., Kosek, J., Kang, J., Amantangelo, M. D., Waldman, M., Lopez-Girona, A., Cai, T., Pourdehnad, M., Trotter, M., Daniel, T. O., Schafer, P. H., Klippel, A., Thakurta, A., Chopra, R.,Gand Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.
| Product Name |
CC-122 |
| Synonyms |
Avadomide |
| CAS Number |
1015474-32-4 |
| Related CAS |
|
| Molecular Formula |
C14H14N4O3 |
| Molecular Weight |
286.291 |
| SMILES |
CC1=NC2=CC=CC(N)=C2C(=O)N1C1CCC(=O)NC1=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
