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CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 promotes degradation of GSPT1. Reference: Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.Hansen, J. D., Correa, M., Alexander, M., Nagy, M., Huang, D., Sapienza, J., Lu, G., LeBrun, L. A., Cathers, B. E., Zhang, W., Tang, Y., Ammirante, M., Narla, R. K., Piccotti, J. R., Pourdehnad, M.,Lopez-Girona, A., CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. Journal of Medicinal Chemistry 2021, 64, 1835-1843.
Product Name CC-885
CAS Number 1010100-07-8
Related CAS
Molecular Formula C22H21ClN4O4
Molecular Weight 440.88
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only