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CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 promotes degradation of GSPT1.

Product Name CC-885
CAS Number 1010100-07-8
Related CAS
Molecular Formula C22H21ClN4O4
Molecular Weight 440.88
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.Hansen, J. D., Correa, M., Alexander, M., Nagy, M., Huang, D., Sapienza, J., Lu, G., LeBrun, L. A., Cathers, B. E., Zhang, W., Tang, Y., Ammirante, M., Narla, R. K., Piccotti, J. R., Pourdehnad, M.,Lopez-Girona, A., CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. Journal of Medicinal Chemistry 2021, 64, 1835-1843.



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