CC-885 is a cereblon (CRBN) modulator with potent anti-tumour activity. CC-885 promotes degradation of GSPT1. Reference: Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.Hansen, J. D., Correa, M., Alexander, M., Nagy, M., Huang, D., Sapienza, J., Lu, G., LeBrun, L. A., Cathers, B. E., Zhang, W., Tang, Y., Ammirante, M., Narla, R. K., Piccotti, J. R., Pourdehnad, M.,Lopez-Girona, A., CC-90009: A Cereblon E3 Ligase Modulating Drug That Promotes Selective Degradation of GSPT1 for the Treatment of Acute Myeloid Leukemia. Journal of Medicinal Chemistry 2021, 64, 1835-1843.
| Product Name |
CC-885 |
| Synonyms |
|
| CAS Number |
1010100-07-8 |
| Related CAS |
|
| Molecular Formula |
C22H21ClN4O4 |
| Molecular Weight |
440.88 |
| SMILES |
CC1=CC=C(NC(=O)NCC2=CC3=C(C=C2)C(=O)N(C3)C2CCC(=O)NC2=O)C=C1Cl |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
