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CC-92480 promotes rapid and extensive degradation of Aiolos/Ikaros than s lenalidomide and pomalidomide.

Product Name CC-92480
Synonyms Mezigdomide
CAS Number 2259648-80-9
Related CAS
Molecular Formula C32H30FN5O4
Molecular Weight 567.621
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


Hansen, J. D., Correa, M., Nagy, M. A., Alexander, M., Plantevin, V., Grant, V., Whitefield, B., Huang, D., Kercher, T., Harris, R., Narla, R. K., Leisten, J., Tang, Y., Moghaddam, M., Ebinger, K., Piccotti, J., Havens, C. G., Cathers, B., Carmichael, J., Daniel, T., Vessey, R., Hamann, L. G., Leftheris, K., Mendy, D., Baculi, F., LeBrun, L. A., Khambatta, G.,Lopez-Girona, A., Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma. Journal of Medicinal Chemistry 2020, 63, 6648-6676.



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