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CC-92480 promotes rapid and extensive degradation of Aiolos/Ikaros than s lenalidomide and pomalidomide. Reference: Hansen, J. D., Correa, M., Nagy, M. A., Alexander, M., Plantevin, V., Grant, V., Whitefield, B., Huang, D., Kercher, T., Harris, R., Narla, R. K., Leisten, J., Tang, Y., Moghaddam, M., Ebinger, K., Piccotti, J., Havens, C. G., Cathers, B., Carmichael, J., Daniel, T., Vessey, R., Hamann, L. G., Leftheris, K., Mendy, D., Baculi, F., LeBrun, L. A., Khambatta, G.,Lopez-Girona, A., Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma. Journal of Medicinal Chemistry 2020, 63, 6648-6676.
Product Name CC-92480
Synonyms Mezigdomide
CAS Number 2259648-80-9
Related CAS
Molecular Formula C32H30FN5O4
Molecular Weight 567.621
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only