CC-92480 promotes rapid and extensive degradation of Aiolos/Ikaros than s lenalidomide and pomalidomide. Reference: Hansen, J. D., Correa, M., Nagy, M. A., Alexander, M., Plantevin, V., Grant, V., Whitefield, B., Huang, D., Kercher, T., Harris, R., Narla, R. K., Leisten, J., Tang, Y., Moghaddam, M., Ebinger, K., Piccotti, J., Havens, C. G., Cathers, B., Carmichael, J., Daniel, T., Vessey, R., Hamann, L. G., Leftheris, K., Mendy, D., Baculi, F., LeBrun, L. A., Khambatta, G.,Lopez-Girona, A., Discovery of CRBN E3 Ligase Modulator CC-92480 for the Treatment of Relapsed and Refractory Multiple Myeloma. Journal of Medicinal Chemistry 2020, 63, 6648-6676. https://doi.org/10.1021/acs.jmedchem.9b01928
| Product Name |
CC-92480 |
| Synonyms |
Mezigdomide |
| CAS Number |
2259648-80-9 |
| Related CAS |
|
| Molecular Formula |
C32H30FN5O4 |
| Molecular Weight |
567.621 |
| SMILES |
[H][C@@]1(CCC(=O)NC1=O)N1CC2=C(C=CC=C2OCC2=CC=C(CN3CCN(CC3)C3=C(F)C=C(C=C3)C#N)C=C2)C1=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
