Golcadomide (CC-99282) is a potent and orally active cereblon (CRBN) E3 ligase modulator. Golcadomide promotes potent and targeted degradation of Ikaros and Aiolos. Reference: Mullard, A., Targeted protein degraders crowd into the clinic. Nat Rev Drug Discov 2021, 20, 247-250.
Product Name |
CC-99282 |
Synonyms |
|
CAS Number |
2379572-34-4 |
Related CAS |
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Molecular Formula |
C28H30FN5O5 |
Molecular Weight |
535.576 |
SMILES |
[H][C@@]1(CCC(=O)NC1=O)N1C(=O)C2=C(C1=O)C(NCC1=CC=C(CN3CC(C3)N3CCOCC3)C=C1F)=CC=C2 |
Purity (HPLC) |
98% |
Shipping Conditions |
Room Temperature |
Storage Conditions |
Refrigerated |
Regulatory Statemen: |
For Research Use Only |