Golcadomide (CC-99282) is a potent and orally active cereblon (CRBN) E3 ligase modulator. Golcadomide promotes potent and targeted degradation of Ikaros and Aiolos. Reference: Mullard, A., Targeted protein degraders crowd into the clinic. Nat Rev Drug Discov 2021, 20, 247-250.
| Product Name |
CC-99282 |
| Synonyms |
|
| CAS Number |
2379572-34-4 |
| Related CAS |
|
| Molecular Formula |
C28H30FN5O5 |
| Molecular Weight |
535.576 |
| SMILES |
[H][C@@]1(CCC(=O)NC1=O)N1C(=O)C2=C(C1=O)C(NCC1=CC=C(CN3CC(C3)N3CCOCC3)C=C1F)=CC=C2 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
