CDg18 (M2 macrophage live cell dye)

$290.00

T01223-1mg

Size: 1mg

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CDg18 is the first M2 macrophage selective fluorescent probe. The selectivity of CDg18 over M2 macrophage has a novel mechanism of gating-oriented live-cell distinction through M2-favored fatty acid transporters. It has been demonstrated that CDg18 can be used to visualize the progressive phenotypic change of M2 toward M1 using a resveratrol analogue HS-1793 as a reprogramming effector. Combined together with M1 probe CDr17, the diminishing M2 character and emerging M1 markers could be simultaneously monitored in real time through the multicolor changes during macrophage reprogramming. Excitation maximum = 444 nm; emission maximum = 525 nm.

Product Name CDg18
Synonyms
CAS Number N/A
Related CAS
Molecular Formula C33H48N2O4
Molecular Weight 536.757
Purity (HPLC) >= 95%
Physical Appearance Yellow solid
Optical Properties Abs/Em Maxima: 444/525 nm
Solubility DMSO
Shipping Conditions Shipped on gel packs
Storage Conditions Store at -20°C and protected from light
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Cho, H., Kwon, H. Y., Lee, S. H., Lee, H. G., Kang, N. Y., & Chang, Y. T. (2023). Development of a Fluorescent Probe for M2 Macrophages via Gating-Oriented Live-Cell Distinction. Journal of the American Chemical Society, 145(5), 2951–2957. https://doi.org/10.1021/jacs.2c11393

 

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