CDr17 (M1 macrophage live cell probe)

CDr17 is a selective small-molecule fluorescent probe for M1 macrophages. The molecular target of CDr17 is GLUT1. GLUT1 was validated to be highly expressed in M1 than M0 and M2 macrophages, and CDr17 utilizes GLUT1 to enter M1 macrophages. CDr17 has been demonstrated to track M1 macrophages in vivo in a rheumatoid arthritis animal model. Excitation maximum = 649 nm; emission maximum = 672 nm. Reference: Cho, H., Kwon, H. Y., Sharma, A., Lee, S. H., Liu, X., Miyamoto, N., Kim, J. J., Im, S. H., Kang, N. Y., & Chang, Y. T. (2022). Visualizing inflammation with an M1 macrophage selective probe via GLUT1 as the gating target. Nature Communications, 13(1). https://doi.org/10.1038/s41467-022-33526-z