CFT7455 is a cereblon E3 ligase modulator with high affinity (Kd of 0.9 nM). CFT7455 acts as a molecular glue. It is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader. Reference: Mullard, A., Targeted protein degraders crowd into the clinic. Nat Rev Drug Discov 2021, 20, 247-250.
| Product Name |
CFT7455 |
| Synonyms |
|
| CAS Number |
2504235-67-8 |
| Related CAS |
|
| Molecular Formula |
C28H27N3O4 |
| Molecular Weight |
469.541 |
| SMILES |
[H][C@@]1(CCC(=O)NC1=O)N1C(=O)C2=C3C1=CC=C(CC1=CC=C(CN4CCOCC4)C=C1)C3=CC=C2 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
