CFT7455

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T55031-5mg

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CFT7455 is a cereblon E3 ligase modulator with high affinity (Kd of 0.9 nM). CFT7455 acts as a molecular glue. It is an orally active zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3) degrader.

Product Name CFT7455
Synonyms
CAS Number 2504235-67-8
Related CAS
Molecular Formula C28H27N3O4
Molecular Weight 469.541
SMILES [H][C@@]1(CCC(=O)NC1=O)N1C(=O)C2=C3C1=CC=C(CC1=CC=C(CN4CCOCC4)C=C1)C3=CC=C2
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Mullard, A., Targeted protein degraders crowd into the clinic. Nat Rev Drug Discov 2021, 20, 247-250.

 

Documents 

Datasheet         COA           MSDS

 

Citations

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