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Chloroquinaxoline sulfonamide (CQS) are aryl sulfonamides with anticancer activity. Chloroquinaxoline sulfonamide (CQS) share the same mechanism of action as Indisulam. Chloroquinaxoline sulfonamide (CQS) promotes the recruitment of RBM39 (RNA binding motif protein 39) to the CUL4-DCAF15 E3 ubiquitin ligase for degadation.

Product Name Chlorsulfaquinoxaline
Synonyms NSC 339004
CAS Number 97919-22-7
Related CAS
Molecular Formula C14H11ClN4O2S
Molecular Weight 334.78
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


Han, T., Goralski, M., Gaskill, N., Capota, E., Kim, J., Ting, T. C., Xie, Y., Williams, N. S.,Nijhawan, D., Anticancer sulfonamides target splicing by inducing RBM39 degradation via recruitment to DCAF15. Science 2017, 356, eaal3755. DOI: 10.1126/science.aal3755



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