Compound 2ab is a more potent E2 enzyme inhibitor than CC0651. It stabilizes the noncovalent CDC34A-donor ubiquitin complex . Reference: St-Cyr, D., Ceccarelli, D. F., Orlicky, S., van der Sloot, A. M., Tang, X., Kelso, S., Moore, S., James, C., Posternak, G., Coulombe-Huntington, J., Bertomeu, T., Marinier, A., Sicheri, F., & Tyers, M. (2021). Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex. Science Advances, 7(44).
| Product Name |
Compound 2ab |
| Synonyms |
|
| CAS Number |
n/a |
| Related CAS |
|
| Molecular Formula |
C24H28Cl2N2O3 |
| Molecular Weight |
463.4 |
| SMILES |
CCNC(=O)C1(CC2=CC=C(C=C2)C2=CC(Cl)=CC(Cl)=C2)CCN(CC1)C(=O)COC |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
