Compound 2ab

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T55022-5mg

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Compound 2ab is a more potent E2 enzyme inhibitor than CC0651. It stabilizes the noncovalent CDC34A-donor ubiquitin complex .

Product Name Compound 2ab
Synonyms
CAS Number n/a
Related CAS
Molecular Formula C24H28Cl2N2O3
Molecular Weight 463.4
SMILES CCNC(=O)C1(CC2=CC=C(C=C2)C2=CC(Cl)=CC(Cl)=C2)CCN(CC1)C(=O)COC
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

St-Cyr, D., Ceccarelli, D. F., Orlicky, S., van der Sloot, A. M., Tang, X., Kelso, S., Moore, S., James, C., Posternak, G., Coulombe-Huntington, J., Bertomeu, T., Marinier, A., Sicheri, F., & Tyers, M. (2021). Identification and optimization of molecular glue compounds that inhibit a noncovalent E2 enzyme-ubiquitin complex. Science Advances, 7(44).

 

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Citations

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