Compound I-13 induces degradation of Ikaros (IKZF1) through recruitment of CRBN( EC50: 0.006 uM). Reference: Axford, J., Beckwith, R. E. J., BONAZZI, S., Buschmann, N., CERNIJENKO, A., DEWHURST, J., FAZAL, A., HESSE, M. J., HOLDER, L., HORNAK, V., Imase, H., Jain, R., Jin, X., Kerrigan, J. R., Lachal, J., Ma, F., Malik, H. A., MANNING, J. R., Mckay, D., MOREAU, R. J., NIMSGERN, P., O'Brien, G., Vulpetti, A., Yamada, K.,Zhao, J. Glue degraders and methods of use thereof. WO 2021/053555, 2021.
| Product Name |
compound I-13 |
| Synonyms |
|
| CAS Number |
2631059-94-2 |
| Related CAS |
|
| Molecular Formula |
C12H11N3O3 |
| Molecular Weight |
245.238 |
| SMILES |
CC1=CC2=C(C=C1)C(=NO2)N1CCC(=O)NC1=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
