dCeMM3 (Compound 3) is a glue degrader. dCeMM3 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. Reference: Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I. H., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Müller, A. C., Zuber, J., Geyer, M., Thomä, N. H., Kubicek, S.,Winter, G. E., Rational discovery of molecular glue degraders via scalable chemical profiling. Nature Chemical Biology 2020, 16, 1199-1207. https://doi.org/10.1038/s41589-020-0594-x
| Product Name |
dCeMM3 |
| Synonyms |
|
| CAS Number |
311787-85-6 |
| Related CAS |
|
| Molecular Formula |
C14H11ClN4OS |
| Molecular Weight |
318.78 |
| SMILES |
ClC1=CN=C(NC(=O)CSC2=NC3=CC=CC=C3N2)C=C1 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
