dCeMM3

T55040-5mg

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dCeMM3 (Compound 3) is a glue degrader. dCeMM3 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex. Reference: Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I. H., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Müller, A. C., Zuber, J., Geyer, M., Thomä, N. H., Kubicek, S.,Winter, G. E., Rational discovery of molecular glue degraders via scalable chemical profiling. Nature Chemical Biology 2020, 16, 1199-1207. https://doi.org/10.1038/s41589-020-0594-x
Product Name dCeMM3
Synonyms
CAS Number 311787-85-6
Related CAS
Molecular Formula C14H11ClN4OS
Molecular Weight 318.78
SMILES ClC1=CN=C(NC(=O)CSC2=NC3=CC=CC=C3N2)C=C1
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only