dCeMM4
dCeMM4 - 5mg is backordered and will ship as soon as it is back in stock.
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dCeMM4 (Compound 5) is a glue degrader. dCeMM4 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.
| Product Name | dCeMM4 |
| Synonyms | |
| CAS Number | 1281683-44-0 |
| Related CAS | |
| Molecular Formula | C14H15N3O3S2 |
| Molecular Weight | 337.41 |
| SMILES | CC1=CC=C(O1)C(=O)N1CSCC1C(=O)NC1=NC=C(C)S1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I. H., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Müller, A. C., Zuber, J., Geyer, M., Thomä, N. H., Kubicek, S.,Winter, G. E., Rational discovery of molecular glue degraders via scalable chemical profiling. Nature Chemical Biology 2020, 16, 1199-1207.https://doi.org/10.1038/s41589-020-0594-x
Documents
Datasheet COA MSDS
Citations
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