dCeMM4

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T55041-5mg

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dCeMM4 (Compound 5) is a glue degrader. dCeMM4 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex.

Product Name dCeMM4
Synonyms
CAS Number 1281683-44-0
Related CAS
Molecular Formula C14H15N3O3S2
Molecular Weight 337.41
SMILES CC1=CC=C(O1)C(=O)N1CSCC1C(=O)NC1=NC=C(C)S1
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


References

Mayor-Ruiz, C., Bauer, S., Brand, M., Kozicka, Z., Siklos, M., Imrichova, H., Kaltheuner, I. H., Hahn, E., Seiler, K., Koren, A., Petzold, G., Fellner, M., Bock, C., Müller, A. C., Zuber, J., Geyer, M., Thomä, N. H., Kubicek, S.,Winter, G. E., Rational discovery of molecular glue degraders via scalable chemical profiling. Nature Chemical Biology 2020, 16, 1199-1207.https://doi.org/10.1038/s41589-020-0594-x

 

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