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GW5074 reduces mHTT levels through autophagic degradation by interacting with both the autophagosome protein microtubule-associated protein 1A/1B light chain 3 (LC3)1 and mutant huntingtin protein (mHTT). It is also a potent and selective c-Raf inhibitor with IC50 of 9 nM. Reference: Li, Z., Wang, C., Wang, Z., Zhu, C., Li, J., Sha, T., Ma, L., Gao, C., Yang, Y., Sun, Y., Wang, J., Sun, X., Lu, C., Difiglia, M., Mei, Y., Ding, C., Luo, S., Dang, Y., Ding, Y., … Lu, B. (2019). Allele-selective lowering of mutant HTT protein by HTT–LC3 linker compounds. Nature, 575(7781), 203–209.
Product Name GW5074
Synonyms 10O5,
CAS Number 220904-83-6
Related CAS
Molecular Formula C15H8Br2INO2
Molecular Weight 520.946
SMILES OC1=C(Br)C=C(\C=C2/C(=O)NC3=C2C=C(I)C=C3)C=C1Br
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only