Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN). It acts as a molecular glue and causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3. Reference: Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.Petzold, G., Fischer, E. S.,Thoma, N. H., Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 2016, 532, 127-30.Sievers, Q. L., Petzold, G., Bunker, R. D., Renneville, A., S?abicki, M., Liddicoat, B. J., Abdulrahman, W., Mikkelsen, T., Ebert, B. L.,Thomä, N. H., Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science 2018, 362, eaat0572.Kronke, J., Udeshi, N. D., Narla, A., Grauman, P., Hurst, S. N., McConkey, M., Svinkina, T., Heckl, D., Comer, E., Li, X., Ciarlo, C., Hartman, E., Munshi, N., Schenone, M., Schreiber, S. L., Carr, S. A.,Ebert, B. L., Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 2014, 343, 301-5.
| Product Name |
Lenalidomide |
| Synonyms |
|
| CAS Number |
191732-72-6 |
| Related CAS |
|
| Molecular Formula |
C13H13N3O3 |
| Molecular Weight |
259.265 |
| SMILES |
NC1=CC=CC2=C1CN(C1CCC(=O)NC1=O)C2=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
