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Lenalidomide is a ligand of ubiquitin E3 ligase cereblon (CRBN). It acts as a molecular glue and causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3. Reference: Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.Petzold, G., Fischer, E. S.,Thoma, N. H., Structural basis of lenalidomide-induced CK1a degradation by the CRL4(CRBN) ubiquitin ligase. Nature 2016, 532, 127-30.Sievers, Q. L., Petzold, G., Bunker, R. D., Renneville, A., S?abicki, M., Liddicoat, B. J., Abdulrahman, W., Mikkelsen, T., Ebert, B. L.,Thomä, N. H., Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science 2018, 362, eaat0572.Kronke, J., Udeshi, N. D., Narla, A., Grauman, P., Hurst, S. N., McConkey, M., Svinkina, T., Heckl, D., Comer, E., Li, X., Ciarlo, C., Hartman, E., Munshi, N., Schenone, M., Schreiber, S. L., Carr, S. A.,Ebert, B. L., Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells. Science 2014, 343, 301-5.
Product Name Lenalidomide
CAS Number 191732-72-6
Related CAS
Molecular Formula C13H13N3O3
Molecular Weight 259.265
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only