MaP555-SNAP (cell-permeable fluorogenic probe)



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MaP555-SNAP is a highly cell-permeable and fluorogenic probe for live-cell imaging. MaP555 is a small-molecule fluorogenic probe with excellent cell permeability. It is converted from 6-carboxytetramethylrhodamine (6-TAMRA) and has similar spectroscopic properties of 6-TAMRA. MaP555 has an acyl sulfamide structure which favors the spirolactam form and thus has excellent cell permeability. When the probe binds to its cellular targets, MaP555 mainly exists in the fluorescent zwitterion form. The good spectroscopic properties, high cell permeability and outstanding fluorogenicity of MaP555 make it very useful for wash-free, multicolour, live-cell nanoscopy. Excitation maximum = 556 nm; emission maximum = 576 nm. Reference: Wang, L., Tran, M., D’Este, E., Roberti, J., Koch, B., Xue, L., & Johnsson, K. (2020). A general strategy to develop cell permeable and fluorogenic probes for multicolour nanoscopy. Nature Chemistry, 12(2), 165–172.

Product Name MaP555-SNAP
CAS Number 2434651-49-5
Related CAS
Molecular Formula C40H40N10O6S
Molecular Weight 788.88
Purity (HPLC) >= 95%
Shipping Conditions Shipped on gel packs
Storage Conditions Store at -20°C and protected from light
Regulatory Statement For Research Use Only