MG-277 is a molecular glue degrader. MG-277 shows very weak activity in inducing degradation of MDM2 and fails to activate p53 but is potent and effective in inducing degradation of GSPT1.
| Product Name | MG-277 |
| Synonyms | |
| CAS Number | 2411085-89-5 |
| Related CAS | |
| Molecular Formula | C41H42Cl2FN5O5 |
| Molecular Weight | 774.72 |
| SMILES | FC1=C(Cl)C=CC=C1[C@H]1[C@@H](NC2(CCCCC2)[C@@]11C(=O)NC2=CC(Cl)=CC=C12)C(=O)NCCCCCC1=C2CN([C@@H]3CCC(=O)NC3=O)C(=O)C2=CC=C1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Yang, J., Li, Y., Aguilar, A., Liu, Z., Yang, C.-Y.,Wang, S., Simple Structural Modifications Converting a Bona fide MDM2 PROTAC Degrader into a Molecular Glue Molecule: A Cautionary Tale in the Design of PROTAC Degraders. Journal of Medicinal Chemistry 2019, 62, 9471-9487.https://doi.org/10.1021/acs.jmedchem.9b00846
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Citations
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