NRX-103095

T55010-5mg

$590.00

5-10 business days

NRX-103095 is an enhancer of the interaction between beta-catenin and beta-TrCP. NRX-103095 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome. Reference: Simonetta, K. R., Taygerly, J., Boyle, K., Basham, S. E., Padovani, C., Lou, Y., Cummins, T. J., Yung, S. L., von Soly, S. K., Kayser, F., Kuriyan, J., Rape, M., Cardozo, M., Gallop, M. A., Bence, N. F., Barsanti, P. A.,Saha, A., Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 2019, 10, 1402. https://doi.org/10.1038/s41467-019-09358-9
Product Name NRX-103095
Synonyms
CAS Number 2763260-38-2
Related CAS
Molecular Formula C22H16Cl2F3N3O3S
Molecular Weight 530.34
SMILES CN(C)C(=O)C1=CC=CC(NC(=O)C2=C(SC3=C(Cl)C=CC=C3Cl)C=C(NC2=O)C(F)(F)F)=C1
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only