NRX-252114 is an enhancer of the interaction between beta-catenin and beta-TrCP. NRX-252114 acts as molecular
glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome. Reference: Simonetta, K. R., Taygerly, J., Boyle, K., Basham, S. E., Padovani, C., Lou, Y., Cummins, T. J., Yung, S. L., von Soly, S. K., Kayser, F., Kuriyan, J., Rape, M., Cardozo, M., Gallop, M. A., Bence, N. F., Barsanti, P. A.,Saha, A., Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 2019, 10, 1402.
| Product Name |
NRX-252114 |
| Synonyms |
|
| CAS Number |
2763260-39-3 |
| Related CAS |
|
| Molecular Formula |
C29H17Cl2F3N4O3S |
| Molecular Weight |
629.44 |
| SMILES |
FC(F)(F)C1=CC(SC2=C(Cl)C=CC=C2Cl)=C(C(=O)N2CC3=CC=CC(C#N)=C3C2)C(=O)N1 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
