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NRX-252262 is an enhancer of the interaction between beta-catenin and beta-TrCP. NRX-252262 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta-catenin by the 26S proteasome. Reference: Simonetta, K. R., Taygerly, J., Boyle, K., Basham, S. E., Padovani, C., Lou, Y., Cummins, T. J., Yung, S. L., von Soly, S. K., Kayser, F., Kuriyan, J., Rape, M., Cardozo, M., Gallop, M. A., Bence, N. F., Barsanti, P. A.,Saha, A., Prospective discovery of small molecule enhancers of an E3 ligase-substrate interaction. Nature Communications 2019, 10, 1402.
Product Name NRX-252262
CAS Number 2438637-61-5
Related CAS
Molecular Formula C30H22Cl2F3N3O5S
Molecular Weight 664.48
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only