Pomalidomide acts as molecular glue. Pomalidomide interacts with the E3 ligase cereblon and induces degradation of essential Ikaros transcription factors. Reference: Dong, G., Ding, Y., He, S.,Sheng, C., Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery. Journal of Medicinal Chemistry 2021, 64, 10606-10620.Fischer, E. S., Bohm, K., Lydeard, J. R., Yang, H., Stadler, M. B., Cavadini, S., Nagel, J., Serluca, F., Acker, V., Lingaraju, G. M., Tichkule, R. B., Schebesta, M., Forrester, W. C., Schirle, M., Hassiepen, U., Ottl, J., Hild, M., Beckwith, R. E., Harper, J. W., Jenkins, J. L.,Thoma, N. H., Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 2014, 512, 49-53.
| Product Name |
Pomalidomide |
| Synonyms |
Revlimid |
| CAS Number |
19171-19-8 |
| Related CAS |
|
| Molecular Formula |
C13H11N3O4 |
| Molecular Weight |
273.248 |
| SMILES |
NC1=CC=CC2=C1C(=O)N(C1CCC(=O)NC1=O)C2=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
