SJ6986, a novel and potent GSPT1 degrader displaying selectivity over 9000 proteins, including the classical IMiD neosubstrates such as IKZF1. SJ6986 has very good oral bioavailability (F = 84% in mice).
| Product Name | SJ6986 |
| Synonyms | |
| CAS Number | n/a |
| Related CAS | |
| Molecular Formula | C20H14F3N3O7S |
| Molecular Weight | 497.4 |
| SMILES | FC(F)(F)OC1=C(C=CC=C1)S(=O)(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Nishiguchi, G., Keramatnia, F., Min, J., Chang, Y., Jonchere, B., Das, S., Actis, M., Price, J., Chepyala, D., Young, B., McGowan, K., Slavish, P. J., Mayasundari, A., Jarusiewicz, J. A., Yang, L., Li, Y., Fu, X., Garrett, S. H., Papizan, J. B., Kodali, K., Peng, J., Pruett Miller, S. M., Roussel, M. F., Mullighan, C., Fischer, M.,Rankovic, Z., Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. Journal of Medicinal Chemistry 2021, 64, 7296-7311. https://doi.org/10.1021/acs.jmedchem.0c01313
Documents
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Citations
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