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SJ6986, a novel and potent GSPT1 degrader displaying selectivity over 9000 proteins, including the classical IMiD neosubstrates such as IKZF1. SJ6986 has very good oral bioavailability (F = 84% in mice). Reference: Nishiguchi, G., Keramatnia, F., Min, J., Chang, Y., Jonchere, B., Das, S., Actis, M., Price, J., Chepyala, D., Young, B., McGowan, K., Slavish, P. J., Mayasundari, A., Jarusiewicz, J. A., Yang, L., Li, Y., Fu, X., Garrett, S. H., Papizan, J. B., Kodali, K., Peng, J., Pruett Miller, S. M., Roussel, M. F., Mullighan, C., Fischer, M.,Rankovic, Z., Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. Journal of Medicinal Chemistry 2021, 64, 7296-7311.
Product Name SJ6986
CAS Number n/a
Related CAS
Molecular Formula C20H14F3N3O7S
Molecular Weight 497.4
Purity (HPLC) 98%
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Regulatory Statemen: For Research Use Only