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SJ6986, a novel and potent GSPT1 degrader displaying selectivity over 9000 proteins, including the classical IMiD neosubstrates such as IKZF1. SJ6986 has very good oral bioavailability (F = 84% in mice).

Product Name SJ6986
CAS Number n/a
Related CAS
Molecular Formula C20H14F3N3O7S
Molecular Weight 497.4
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


Nishiguchi, G., Keramatnia, F., Min, J., Chang, Y., Jonchere, B., Das, S., Actis, M., Price, J., Chepyala, D., Young, B., McGowan, K., Slavish, P. J., Mayasundari, A., Jarusiewicz, J. A., Yang, L., Li, Y., Fu, X., Garrett, S. H., Papizan, J. B., Kodali, K., Peng, J., Pruett Miller, S. M., Roussel, M. F., Mullighan, C., Fischer, M.,Rankovic, Z., Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. Journal of Medicinal Chemistry 2021, 64, 7296-7311.



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