SJ6986, a novel and potent GSPT1 degrader displaying selectivity over 9000 proteins, including the classical IMiD neosubstrates such as IKZF1. SJ6986 has very good oral bioavailability (F = 84% in mice). Reference: Nishiguchi, G., Keramatnia, F., Min, J., Chang, Y., Jonchere, B., Das, S., Actis, M., Price, J., Chepyala, D., Young, B., McGowan, K., Slavish, P. J., Mayasundari, A., Jarusiewicz, J. A., Yang, L., Li, Y., Fu, X., Garrett, S. H., Papizan, J. B., Kodali, K., Peng, J., Pruett Miller, S. M., Roussel, M. F., Mullighan, C., Fischer, M.,Rankovic, Z., Identification of Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degraders from a Focused Library of Cereblon Modulators. Journal of Medicinal Chemistry 2021, 64, 7296-7311. https://doi.org/10.1021/acs.jmedchem.0c01313
| Product Name |
SJ6986 |
| Synonyms |
|
| CAS Number |
n/a |
| Related CAS |
|
| Molecular Formula |
C20H14F3N3O7S |
| Molecular Weight |
497.4 |
| SMILES |
FC(F)(F)OC1=C(C=CC=C1)S(=O)(=O)NC1=CC2=C(C=C1)C(=O)N(C1CCC(=O)NC1=O)C2=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
