TMX-4100 is a selective phosphodiesterase 6D (PDE6D) degrader. TMX-4100 shows a high degradation preference for PDE6D with the DC50 values less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4100 can be used for the research of multiple myeloma.
| Product Name | TMX-4100 |
| Synonyms | |
| CAS Number | 2367619-63-2 |
| Related CAS | |
| Molecular Formula | C11H10N4O2S |
| Molecular Weight | 262.29 |
| SMILES | O=C1CCC(N2C=C(N=N2)C2=CSC=C2)C(=O)N1 |
| Purity (HPLC) | >= 95% |
| Physical Appearance | White solid |
| Solubility | DMSO, DMF |
| Shipping Conditions | Room Temperature |
| Storage Conditions | Refrigerated |
| Shelf Life | 12 months after the date of delivery |
| Regulatory Statement | For Research Use Only |
References
Teng, M., Lu, W., Donovan, K. A., Sun, J., Krupnick, N. M., Nowak, R. P., Li, Y.-D., Sperling, A. S., Zhang, T., Ebert, B. L., Fischer, E. S.,Gray, N. S., Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216. Journal of Medicinal Chemistry 2022, 65, 747-756.
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