TMX-4116 is a casein kinase 1a (CK1a) degrader. TMX-4116 shows the degradation preference for CK1a with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma. Reference: Teng, M., Lu, W., Donovan, K. A., Sun, J., Krupnick, N. M., Nowak, R. P., Li, Y.-D., Sperling, A. S., Zhang, T., Ebert, B. L., Fischer, E. S.,Gray, N. S., Development of PDE6D and CK1a Degraders through Chemical Derivatization of FPFT-2216. Journal of Medicinal Chemistry 2022, 65, 747-756.
| Product Name |
TMX-4116 |
| Synonyms |
|
| CAS Number |
2766385-56-0 |
| Related CAS |
|
| Molecular Formula |
C17H19N5O4S |
| Molecular Weight |
389.43 |
| SMILES |
COC1=C(SC=C1C1=CN(N=N1)C1CCC(=O)NC1=O)C(=O)N1CCCC1 |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
