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Vepdegestrant (ARV-471) is a PROTAC protein degrader for breast cancer. Vepdegestrant facilitates the interactions between estrogen receptor alpha and an intracellular E3 ligase complex and leads to degradation of ER in ER-positive breast cancer cell lines.

Product Name Vepdegestrant
Synonyms ARV-471
CAS Number 2229711-68-4
Related CAS
Molecular Formula C45H49N5O4
Molecular Weight 723.918
Purity (HPLC) >= 95%
Physical Appearance White solid
Solubility DMSO, DMF
Shipping Conditions Room Temperature
Storage Conditions Refrigerated
Shelf Life 12 months after the date of delivery
Regulatory Statement For Research Use Only


Flanagan JJ, Qian Y, Gough SM, Andreoli M, Bookbinder M, Cadelina G, Bradley J, Rousseau E, Willard R, Pizzano J, Crews CM, Crew AP, Taylor I, Houston J. ARV-471, an oral estrogen receptor PROTAC degrader for breast cancer [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P5-04-18.



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