ZXH-1-161 is a potent cereblon (CRBN) modulator with an IC50 value of 39 nM in MM1.S wild type cells. ZXH-1-161 has selective degradation activity towards GSPT1. ZXH-1-161 can be used for researching multiple myeloma. Reference: Powell, C. E., Du, G., Che, J., He, Z., Donovan, K. A., Yue, H., Wang, E. S., Nowak, R. P., Zhang, T., Fischer, E. S.,Gray, N. S., Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chemical Biology 2020, 15, 2722-2730.
| Product Name |
ZXH-1-161 |
| Synonyms |
|
| CAS Number |
2407654-51-5 |
| Related CAS |
|
| Molecular Formula |
C26H24N6O3 |
| Molecular Weight |
468.517 |
| SMILES |
O=C1N(CC2=C1C=CC=C2NC1=NC(NC2=CC3=C(CCC3)C=C2)=NC=C1)C1CCC(=O)NC1=O |
| Purity (HPLC) |
98% |
| Shipping Conditions |
Room Temperature |
| Storage Conditions |
Refrigerated |
| Regulatory Statemen: |
For Research Use Only |
